MedTrace Logo

Intra Oral Kinetics of Fluoride Containing Dentifrices

NCT02548156 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 29

Last updated 2017-01-18

Study results available
· View outcomes & findings →

Summary

The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of fluoride and calcium ions in saliva over 60 minutes after a single brushing with US marketed fluoridated dentifrices and following a dietary acid challenge post 60 minutes of brushing with study treatment.

Conditions

  • Tooth Erosion

Interventions

OTHER

Test Dentifrice

Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3

OTHER

Reference Dentifrice

Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3

OTHER

Comparator Dentifrice

Marketed dentifrice containing 1150ppm fluoride and 5% w/w KNO3

OTHER

Orange Juice

Teeth will be rinsed with orange juice followed by rinsing with de-ionised water in test dentifrice and comparator dentifrice arms.

OTHER

De-ionised water

Teeth will be rinsed with de-ionised water followed by reference dentifrice and followed by rinsing with orange juice in test dentifrice and comparator dentifrice arms.

Sponsors & Collaborators

Principal Investigators

  • GSK Clinical Trials · GlaxoSmithKline

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2015-10-31
Completion
2015-10-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02548156 on ClinicalTrials.gov