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Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride

NCT01563172 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 65

Last updated 2018-02-07

Study results available
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Summary

This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).

Conditions

  • Dental Caries

Interventions

DRUG

Sodium fluoride / silica and carbopol, 0.5g

Dentifrice containing 1150 parts per million (ppm) fluoride as sodium fluoride / silica and 0.4% carbopol

DRUG

Sodium fluoride / silica and carbopol, 1.5g

Dentifrice containing 1150 ppm fluoride as sodium fluoride / silica and 0.4% carbopol

DRUG

Sodium fluoride / silica and carbopol, 1.5g

Dentifrice containing 250 ppm fluoride as sodium fluoride / silica and 0.4% carbopol

OTHER

Fluoride free dentifrice

A non fluoride dentifrice was given to participants of each arm at washout period

Sponsors & Collaborators

Principal Investigators

  • GSK Clinical Trials · GlaxoSmithKline

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-01-01
Primary Completion
2009-06-01
Completion
2009-06-01

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01563172 on ClinicalTrials.gov