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Evaluation of the Anticaries Efficacy of Dentifrice Formulations Using an In-situ Model

NCT06140758 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2024-02-29

No results posted yet for this study

Summary

The primary objective is to compare the remineralization and demineralization inhibition potential of early subsurface carious lesions in enamel in situ after rinsing with six different aqueous slurries of toothpaste formulations.

Conditions

  • Caries

Interventions

DRUG

Oral-B 1450 ppm Fluoride (1.16% sodium monofluorophosphate) Dentifrice

Each subject will use this product during one of the six treatment periods in the crossover study design.

DRUG

Colgate 1450 ppm Fluoride (1.16% sodium monofluorophosphate)Dentifrice

Each subject will use this product during one of the six treatment periods in the crossover study design.

DRUG

Toms of Maine 0 ppm Fluoride Dentifrice

Each subject will use this product during one of the six treatment periods in the crossover study design.

DRUG

Colgate 1450 ppm Fluoride (1.1% sodium monofluorophosphate) Dentifrice

Each subject will use this product during one of the six treatment periods in the crossover study design.

DRUG

1500 ppm MFP/CaCO3 1.16% sodium monofluorophosphate) Dentifrice

Each subject will use this product during one of the six treatment periods in the crossover study design.

DRUG

1100 ppm (0.454% Stannous fluoride) Dentifrice

Each subject will use this product during one of the six treatment periods in the crossover study design.

Sponsors & Collaborators

  • Procter and Gamble

    lead INDUSTRY

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-31
Primary Completion
2023-12-11
Completion
2023-12-11

Countries

  • Australia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06140758 on ClinicalTrials.gov