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A Clinical Study to Assess an Experimental Dentifrice in an Experimental Model of Early Stage Caries

NCT06949072 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 47

Last updated 2025-09-24

No results posted yet for this study

Summary

The aim of this study is to evaluate the relative efficacy of an experimental dentifrice containing 1150 parts per million (ppm) fluoride (as sodium fluoride \[NaF\]) to remineralize early stage caries type lesions in an in situ model compared to a negative control and a reference dentifrice.

Conditions

  • Dental Caries

Interventions

DRUG

Test Dentifrice

Dentifrice containing 5 percent (%) weight by weight (w/w) Potassium nitrate (KNO3) and 1150ppm fluoride as sodium fluoride.

DRUG

Reference Dentifrice

Dentifrice containing 1100ppm fluoride as stannous fluoride.

DRUG

Negative Control Dentifrice

Dentifrice containing 5% KNO3 with no fluoride.

Sponsors & Collaborators

  • HALEON

    lead INDUSTRY

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-04-28
Primary Completion
2025-09-11
Completion
2025-09-11

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06949072 on ClinicalTrials.gov