Myocardial Perfusion Quantification With SPECT Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary CTA

Summary

This prospective study aims to compare functional abnormalities detected using myocardial perfusion SPECT imaging (MPI SPECT) with the extent and severity of anatomical findings on coronary computed tomography angiography (coronary CTA). Additionally, the investigators aim to enhance the diagnostic value of MPI SPECT by quantifying myocardial blood flow and utilizing myocardial flow reserve calculated from dynamic SPECT images.

50 patients with suspected coronary artery disease are anticipated to be enrolled. Pharmacological stress and rest-phase dynamic and static MPI SPECT following an additional coronary CTA scan are to be performed. The obtained multimodality imaging data (functional and anatomical parameters) are planned to be compared and subjected to statistical analysis. The results of this study are expected to improve risk assessment for patients with moderate cardiovascular risk and enhance the diagnostic performance of MPI SPECT.

Conditions

• Coronary Artery Disease
• Coronary Computed Tomography Angiography
• SPECT
• Heart Diseases
• Cardiovascular Diseases
• Arteriosclerosis
• Myocardial Ischemia
• Coronary Disease
• Chest Pain

Interventions

DIAGNOSTIC_TEST

Stress Dynamic MPI SPECT

BMI standardized radiopharmaceutical injection in pharmacological stress (dipyridamole or adenosine) is performed under the SPECT camera to record the temporal distribution of the activity. A one-day protocol and multi-pinhole collimator are used.

DIAGNOSTIC_TEST

Stress Static MPI SPECT

30-60 minutes after stress dynamic SPECT imaging is performed, an ECG-gated static SPECT MPI is conducted with a conventional LEHR collimator.

DIAGNOSTIC_TEST

Rest Dynamic MPI SPECT

3 hours after the stress phase, the rest phase is also recorded. A radiopharmaceutical injection with a three-fold dose at rest is performed under the SPECT camera to record the temporal distribution of the activity. A one-day protocol and multi-pinhole collimator are used.

DIAGNOSTIC_TEST

Rest Static MPI SPECT

30-60 minutes after rest, dynamic SPECT imaging is performed, and an ECG-gated static SPECT MPI is conducted with a conventional LEHR collimator.

DIAGNOSTIC_TEST

Cardiac CT

Within 30 days of MPI SPECT imaging, a cardiac CT is performed for every patient, including a native calcium-scoring scan and a coronary CT angiography as a reference standard. A photon-counting detector CT is used.

Sponsors & Collaborators

• Semmelweis University

  lead OTHER

Principal Investigators

• Pál Maurovich-Horvat, Prof. Dr. · Semmelweis University Medical Imaging Centre

• Tamás Györke, MD · Semmelweis University Department of Nuclear Medicine

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-03-06

Primary Completion

2025-08-30

Completion

2026-08-30

Countries

• Hungary

Study Locations