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Comparison of Quantitative MRI Perfusion Methods With Quantitative PET Perfusion Imaging

NCT02608944 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2020-09-14

No results posted yet for this study

Summary

This work seeks to develop, evaluate and use new MRI methods for non-invasive quantitative assessment of myocardial perfusion and perfusion reserve (MPR), and to compare with quantitative PET imaging.

Conditions

  • MRI Scans

Interventions

DRUG

Adenosine

Adenosine: 0.14mg/kg/min for 6 min. IV injection for MRI perfusion

DRUG

Regadenoson

Regadenoson: 0.4mg in 5ml, given as a rapid (10 seconds) IV injection for MRI perfusion.

DRUG

O-15 labeled radioactive water

O-15 labeled radioactive water: Up to 50mCi IV injection at rest and again at hyperemia for PET Imaging

DEVICE

MRI

Pass dynamic contrast enhanced MRI scans will be performed at rest and during hyperemia caused by either adenosine infusion or regadenoson

DEVICE

PET Imaging

Quantitative PET imaging with O-15 labeled radioactive water will be given at a different day.

Sponsors & Collaborators

Principal Investigators

  • Edward DiBella, Ph.D. · University of Utah

Study Design

Allocation
NA
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2012-09-30
Primary Completion
2019-06-12
Completion
2019-06-12

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02608944 on ClinicalTrials.gov