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Assessment of Oxygen Changes in the Heart With Cardio-vascular Magnetic Resonance Imaging

NCT00693758 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2011-10-04

No results posted yet for this study

Summary

The ability of a new SSFP-based BOLD MRI sequence to assess myocardial oxygenation changes in response to coronary flow changes induced by adenosine and increased CO2-partial pressure will be examined in healthy volunteers and patients with suspected coronary artery disease. Also the susceptibility of a new SSFP-based BOLD sensitive MRI sequence to changes in arterial oxygenation will be examined. This will help understand the physiologic basis of oxygen sensitive imaging of the heart.

Conditions

  • Vascular Diseases
  • Myocardial Ischemia

Interventions

DRUG

adenosine

intravenous infusion of adenosine (140microgr./min/kg)

OTHER

modified end-tidal forcing system

changes in partial pressures of O2 and CO2 in inspired air

OTHER

arm cuff occlusion

3 min. lasting upper arm cuff occlusion

DEVICE

Breathing gas

Changes in pO2 and pCO2 in inspired air mix

DEVICE

Blood pressure cuff

supra-systolic arm occlusion with pressure cuff

Sponsors & Collaborators

  • University of Calgary

    lead OTHER

Principal Investigators

  • Matthias Friedrich, MD · University of Calgary

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-31
Primary Completion
2011-09-30
Completion
2011-09-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00693758 on ClinicalTrials.gov