Diet and Rheumatoid Arthritis Risk in the United Kingdom Women's Cohort

Summary

Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that requires lifelong treatment and represents a significant burden for both the individual and society. Diet can affect inflammatory status and RA risk, with varying risks for women on specific diets. Low to moderate levels of alcohol consumption may be associated with lower risk of RA, and those who do not consume enough fruit and vegetables could be at a greater risk than those with adequate intakes. Our research aim is to better understand the role of diet in reducing RA risk in United Kingdom women. The research will use existing dietary and lifestyle data from the United Kingdom Women's Cohort Study and hospital records of RA incidence.

Conditions

• Rheumatoid Arthritis (RA)

Interventions

OTHER

Dietary pattern

(regular meat-eater, occasional meat-eater, fish-eater, vegetarian, and vegan; Mediterranean diet)

OTHER

Alcohol intake

(Frequency and intake of beer, wine, sherry, and spirits were collected by asking the number of specified units (pints, glasses or measures) of each type of alcoholic beverage (beer or cider, wine, sherry or fortified wines, and spirits) per week.)

OTHER

Fruit and vegetables intake

(Intake of fruits, vegetables, fruits and vegetables combined from food frequency questionnaire)

OTHER

Tea consumption

(Intake of tea from food frequency questionnaire)

OTHER

Coffee consumption

(Intake of caffeinated coffee and decaffeinated coffee from food frequency questionnaire)

OTHER

Fish intake

(Intake of fish from food frequency questionnaire)

OTHER

Meat intake

(Intake of red meat, processed meat, and poultry from food frequency questionnaire)

OTHER

Vitamin D intake

(Estimated intake of vitamin D, derived from food frequency questionnaire and any recorded supplemental intake)

Sponsors & Collaborators

• University of Leeds

  lead OTHER

Eligibility

Min Age

36 Years

Max Age

69 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

1995-01-15

Primary Completion

2019-03-13

Completion

2019-03-13

Countries

• United Kingdom

Study Locations