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Dietary Factors and Rheumatoid Arthritis Risk in the UK Biobank

NCT06670183 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 500000

Last updated 2026-05-01

No results posted yet for this study

Summary

Rheumatoid arthritis (RA) is the most common inflammatory arthritis, affecting around 1% of the UK population. It affects around 400,000 adults and is characterised by synovial inflammation, cartilage and bone damage that requires lifelong treatment and represents a significant burden for both the individual and society. Diet can affect inflammatory status and RA risk, with varying risks for men and women on specific diets. People with low to moderate consumption of alcohol may be at a lower risk of RA. Those who consume lower intakes of fruit and vegetables could be at a greater risk than those with adequate intakes. This research aims to better understand the role of diet in reducing RA risk in men and women in the United Kingdom. The research will use existing dietary and lifestyle data from the United Kingdom Biobank Study and hospital records of RA incidence.

Conditions

  • Rheumatoid Arthritis (RA)

Interventions

OTHER

Dietary patterns

Dietary patterns such as regular meat-eater, occasional meat-eater, pescatarian, and vegetarian; Mediterranean diet.

OTHER

Food groups and Nutrients

Dietary components, such as oily fish, dairy product, supplements, fibre, vitamin D supplements.

OTHER

Alcohol intake

Frequency and intake of alcoholic beverages was measured by self-reporting the weekly frequency of different types of alcoholic beverages, e.g., the number of pints of beer/cider consumed per week and measures of spirits or liquors consumed per week were collected to assess consumption of beer/cider and spirits.

OTHER

Vitamin D status

Serum 25(OH)D was measured once at baseline through a non-fasted blood draw during any season of the year.

Sponsors & Collaborators

  • University of Leeds

    lead OTHER

Principal Investigators

  • Darren C Greenwood, PhD · University of Leeds

Eligibility

Min Age
40 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-01-01
Primary Completion
2029-12-31
Completion
2029-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06670183 on ClinicalTrials.gov