Aging, Geriatric Syndromes and Clonal Hematopoiesis

Summary

In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.

Conditions

• Geriatrics
• Aged
• Geriatric Syndromes
• Cardiovascular Diseases

Interventions

OTHER

Cognitive Assessment

-Baseline and no more frequently than every 6 months until death

OTHER

Activities of Daily Living Questionnaire

* 10 items about daily functional status * Baseline and no more frequently than every 6 months until death

OTHER

Instrumental Activities of Daily Living, subscale of the OARS

* 7 items about daily functional status * Baseline and no more frequently than every 6 months until death

OTHER

Karnofsky Self-reported Performance Rating Scale

* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death

OTHER

Number of Falls

* 1 item about daily functional status * Baseline and no more frequently than every 6 months until death

OTHER

Physical Health Section, subscale of the OARS

* 13 items about comorbidity * Baseline and no more frequently than every 6 months until death

OTHER

MOS Social Activity Survey

* 4 items about social activity * Baseline and no more frequently than every 6 months until death

OTHER

Unintentional Weight Loss

* 2 items about nutrition * Baseline and no more frequently than every 6 months until death

GENETIC

Peripheral Blood Draw

-Baseline and no more frequently than every 6 months until death

GENETIC

Buccal Swab

* Participants will rinse their mouths 2 times with water for 20-30 seconds and discard the expectorated sample. One side of the inner cheek (buccal mucosa) will then be scraped with a cotton swab 20 times (alternatively, the tongue will be brushed 20 times with a toothbrush) * Baseline and no more frequently than every 6 months until death

OTHER

Heart Health and Smoking History from BRFSS questionnaire

* 7 items about heart health and smoking history * Baseline and no more frequently than every 6 months until death

OTHER

Gait Speed

* Research coordinator will test gait speed * Baseline and no more frequently than every 6 months until death

OTHER

Grip Strength

* Research coordinator will test grip strength * Baseline and no more frequently than every 6 months until death

OTHER

Height and Weight measurements

-Baseline and no more frequently than every 6 months until death

OTHER

Blood pressure measurement

-Baseline and no more frequently than every 6 months until death

PROCEDURE

Optional bone marrow biopsy

-1 optional bone marrow biopsy

PROCEDURE

Blood draw for trauma measurements

-For Arm E only

OTHER

Femur head donation

Hip replacement participants only

Sponsors & Collaborators

• Edward P. Evans Foundation

  collaborator OTHER

• Washington University School of Medicine

  lead OTHER

Principal Investigators

• Meagan Jacoby, M.D. · Washington University School of Medicine

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-03-10

Primary Completion

2030-04-30

Completion

2030-04-30

Countries

• United States

Study Locations