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New Prognostic and Predictive Biomarkers for HPV-associated Oropharyngeal Cancer

NCT06097936 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2023-10-24

No results posted yet for this study

Summary

The study involves the coexistence of a retrospective part, in which a group of patients with HPV-associated OPC for whom follow-up data of at least 2 years after diagnosis are available, designed in order to evaluate the expression of HPV16-specific E5 transcript as well as that of pEGFR and HLA, and a multicenter prospective part, involving the enrollment of a control group, enrolled at the ENT outpatient clinic of the IRE and the outpatient clinics of the relevant LILT provincial committees, to better elucidate the role of HPV16-E5 in identifying potentially transforming infections due to the presence of HPV.

Conditions

  • PREDICTIVE BIOMARKERS
  • Evaluation of HPV-specific E5 Transcript Expression in a Cohort of Patients With HPV-associated OPC
  • HPV 16 Positive Oropharyngeal Tumors (OPC)

Interventions

DIAGNOSTIC_TEST

HPV-ASSOCIATED OROPHARYNGEAL CANCER

The study involves the coexistence of a retrospective part, in which a group of patients with HPV-associated OPC for whom follow-up data of at least 2 years after diagnosis are available, designed in order to evaluate the expression of HPV16-specific E5 transcript as well as that of pEGFR and HLA, and a multicenter prospective part, involving the enrollment of a control group, enrolled at the ENT outpatient clinic of the IRE and the outpatient clinics of the relevant LILT provincial committees, to better elucidate the role of HPV16-E5 in identifying potentially transforming infections due to the presence of HPV.

Sponsors & Collaborators

Eligibility

Min Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-03-15
Primary Completion
2022-12-13
Completion
2024-04-01

Countries

  • Italy

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06097936 on ClinicalTrials.gov