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Investigating How Childhood Tumours and Congenital Disease Develop

NCT06584877 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2024-09-05

No results posted yet for this study

Summary

Every cell and every organ in the human body derives from a fertilised egg. As the fertilised egg divides, a human being develops and grows. The process of how the fertilised egg divides and forms a human being is very sophisticated and is directed by the genetic information, the DNA, that is present in every cell.

When errors, mutations, in the DNA code arise, the orderly process of human development can be disrupted. This can lead to the development of tumours during childhood and congenital diseases (that is, abnormalities that children are born with).

The aim of this study is to define exactly which DNA errors underpin childhood tumours and congenital diseases.

Conditions

  • Childhood Tumor
  • Congenital Disorders

Interventions

OTHER

sample collection

Surplus material from surgery. New or stored blood or saliva. Semen (from adult males).

OTHER

Seeking consent and assent

Consent or assent from all participants to be included in the study. Consent from parent / guardian for inclusion of children in study (as primary participant or relative/sibling, as applicable).

Sponsors & Collaborators

  • The Wellcome Sanger Institute

    lead OTHER

Principal Investigators

  • Sam Behjati, PhD · The Wellcome Sanger Institute

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-02
Primary Completion
2026-02-28
Completion
2026-02-28

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06584877 on ClinicalTrials.gov