Pcrit and TPP for Risk Stratification in Patients with Sepsis

Summary

The goal of this observational study is to learn about the roles of critical closing pressure and tissue perfusion pressure in monitoring hemodynamic status, evaluating organ damage, and predicting mortality risk in patients with sepsis. The main question it aims to answer is:

• Whether increases in critical closing pressure or tissue perfusion pressure are associated with a reduced risk of poor prognosis?

Within the 24 hours following the diagnosis of sepsis, patients will be categorized into four groups based on their 24-hour mean critical closing pressure (Pcc) and tissue perfusion pressure (TPP) estimated from the hourly hemodynamic data within 24 hours. Outcomes will then be compared across these different groups.

The study has been approved by the Medical Ethics Committee of Peking Union Medical College Hospital (K24C1937 and K25C0792).

Conditions

• Sepsis

Interventions

OTHER

No Intervention: Observational Cohort

No intervention.

Sponsors & Collaborators

• Fu Xing Hospital, Capital Medical University

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• First Hospital of China Medical University

  collaborator OTHER

• Shanghai Zhongshan Hospital

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• China-Japan Friendship Hospital

  collaborator OTHER

• Beijing Friendship Hospital of Captial Medical University (Beijing)

  collaborator UNKNOWN

• Beijing Chao Yang Hospital

  collaborator OTHER

• General Hospital of Ningxia Medical University

  collaborator OTHER

• Xiangya Hospital of Central South University

  collaborator OTHER

• Beijing Tongren Hospital

  collaborator OTHER

• Peking University Third Hospital

  collaborator OTHER

• Xuanwu Hospital, Beijing

  collaborator OTHER

• Beijing Tiantan Hospital

  collaborator OTHER

• Guangdong Provincial People's Hospital

  collaborator UNKNOWN

• Peking Union Medical College Hospital

  lead OTHER

Principal Investigators

• Bin Du · Peking Union Medical College Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-03-01

Primary Completion

2024-08-30

Completion

2024-08-30

Countries

• China

Study Locations