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Study of Biomarkers in Patients of Sepsis Complicated With Gastrointestinal Dysfunction

NCT04647201 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2020-11-30

No results posted yet for this study

Summary

1. Title: Study of Biomarkers in Patients of Sepsis Complicated With Gastrointestinal Dysfunction
2. Research center: Single-center study.
3. Design of the research: A prospective and cohort study.
4. Object of the research: Patients with age≥18 years those who meet the diagnostic criteria of sepsis 3.0 complicated with GI and grouped into GI group and non-GI adults as control.
5. Sample size of the research: Not less than 30 patients in each group.
6. Research approach: After admission to ICU, patients were assigned to the indicated groups according to the criteria. In addition, blood samples were collected within 24 hours for detecting serum levels of HO-1, PINK1, PLK1as well as oxidative stress and inflammatory markers.For those who requiring intestinal surgery as treatment, the intestinal tissue specimens are retained.
7. Aim of the research: The find out the potential biomarkers in serum to help the diagnose and management of gastrointestinal dysfunction in septic patients.
8. Statistical analysis: Analytical study.
9. The estimated duration of the study#1-2 years.

Conditions

  • Sepsis
  • Gastrointestinal Dysfunction

Sponsors & Collaborators

  • Jianbo Yu

    lead OTHER

Principal Investigators

  • Jianbo Yu, PhD · Tianjin Nankai Hospital

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-23
Primary Completion
2021-12-31
Completion
2022-06-30

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04647201 on ClinicalTrials.gov