Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)

Summary

The purposes of this study are to assess rapidly innovative treatment methods in patients with adult respiratory distress syndrome (ARDS) as well as those at risk of developing ARDS and to create a network of interactive Critical Care Treatment Groups (CCTGs) to establish and maintain the required infrastructure to perform multiple therapeutic trials that may involve investigational drugs, approved agents not currently used for treatment of ARDS, or treatments currently used but whose efficacy has not been well documented.

Conditions

• Respiratory Distress Syndrome, Adult
• Lung Diseases

Interventions

PROCEDURE

Low Tidal Volume Ventilation

PROCEDURE

Positive End-Expiratory Pressure

DRUG

Lysofylline

DRUG

Methylprednisolone

DRUG

Ketoconazole

PROCEDURE

Fluid Management

PROCEDURE

Pulmonary Artery Catheter

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  lead NIH

Principal Investigators

• Edward Abraham, MD · University of Colorado, Denver

• Antonio Anzueto, MD · University of Texas

• Roy Brower, MD · Johns Hopkins University

• Alfred F. Connors, MD · University of Virginia

• Bennett P. deBoisblanc, MD · Louisiana State University Health Sciences Center in New Orleans

• Bennett P. deBoisblanc, MD · Louisiana State University Health Science Center

• Michael Donahoe, MD · University of Pittsburgh

• Kalpalatha K. Guntupalli, MD · Baylor College of Medicine

• Robert D. Hite, MD · Wake Forest University

• Robert D. Hite, MD · Wake Forest University Health Sciences

• Rolf Hubmayr, MD · Mayo Clinic

• Neil MacIntyre, MD · Duke University

• Michael A. Matthay, MD · University of California, San Francisco

• Alan Morris, MD · Latter Day Saints Hospital

• Michael J. Murray · Mayo Foundation

• James A. Russell, MD · University of British Columbia

• Gregory A. Schmidt, MD, FCCP · University of Chicago

• David A. Schoenfeld, PhD · Massachusetts General Hospital

• Jay S. Steingrub, MD, FCCP · Baystate Medical Center

• Arthur Wheeler, MD · Vanderbilt University

• Herbert Wiedemann, MD · Cleveland Clinic Lerner College of Medicine

Study Design

Purpose

TREATMENT

Model

FACTORIAL

Eligibility

Min Age

13 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1994-09-30

Completion

2004-07-31

Countries

• United States
• Canada

Study Locations