Skeletal Maturation and Endocrine Health in Young Adults

Summary

Diseases which can be the result of poor lifestyle choices in adult life, such as osteoporosis, obesity or poor muscle mass (sarcopenia) can also be driven by heritable genetic factors. More surprisingly, perhaps, the genes we inherit from our parents can be modified as a result of influences that affected the health and pregnancy of our mothers and hence the environment experienced in the womb and at birth. The purpose of this study is to investigate which factors are needed for good bone health and hormonal health in young adulthood as well as good muscle mass and normal fat mass, and how this is influenced by factors before birth and by childhood health. Specifically, we will measure bone mass and body composition in young adults (18 years of age) and measure hormones in blood and in hair samples. The clinical visits will be available nationwide at several centers to make participation swift and easy for participants. The changes (known as epigenetic modification) to genes at birth will be studied in dried blood spot samples stored from birth 18 years ago in the Danish Serum Institute and we will use national health registers to identify factors during pregnancy and in childhood that contribute to health effects at age 18.

Conditions

• Osteoporosis
• Sarcopenia
• Obesity
• Cardiovascular Diseases

Sponsors & Collaborators

• Aarhus University Hospital

  collaborator OTHER

• Aalborg University Hospital

  collaborator OTHER

• University of Southern Denmark

  collaborator OTHER

• University Hospital Bispebjerg and Frederiksberg

  collaborator OTHER

• Zealand University Hospital

  collaborator OTHER

• Odense University Hospital

  collaborator OTHER

• Rigshospitalet, Denmark

  collaborator OTHER

• Statens Serum Institut

  collaborator OTHER

• Hvidovre University Hospital

  collaborator OTHER

• Holbaek Sygehus

  lead OTHER

Principal Investigators

• Bo Abrahamsen, MD, PhD · OPEN, University of Southern Denmark, Odense and Department of Medicine 1, Holbæk Hospital, Holbæk

• Katrine H Rubin, MHS, PhD · OPEN, Department of Clinical Research, University of Southern Denmark and Odense University Hospital

• Bente Langdahl, MD, PhD · Department of Clinical Medicine and Department of Endocrinology and Diabetes, Aarhus University

• Peter Vestergaard, MD, PhD · Faculty of Medicine, Aalborg University and Department of Endocrinology, Aalborg University Hospital

• Berit L Heitmann, DMD, PhD · The Parker Institute, Frederiksberg Hospital, Frederiksberg

• Mina N Händel, Msc, PhD · The Parker Institute, Frederiksberg Hospital, Frederiksberg

• Charlotte L Tofteng, MD, PhD · Department of CIinical Medicine, Endocrinology, Zealand University Hospital, Køge

• Pernille Bach-Mortensen, MD, PhD · Department of Endocrinology, Amager and Hvidovre Hospital, Hvidovre

• Pernille Hermann, MD, PhD · Department of Endocrinology, Odense University Hospital, Odense

• Niklas R Jørgensen, MD, PhD · Department of Clinical Biochemistry and Centre of Diagnostic Investigation,Rigshospitalet Copenhagen

• Jonas Bybjerg-Grauholm, MSE · Danish Center for Neonatal Screening, Statens Serum Institut, Copenhagen

Eligibility

Min Age

18 Years

Max Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-11-11

Primary Completion

2026-09-30

Completion

2031-09-30

Countries

• Denmark

Study Locations