Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection

Summary

The study will compare the use of cold snare piecemeal resection (CSPR) vs cold endoscopic mucosal resection (Cold EMR). The study will include two cohorts: one cohort for conventional adenomas 10-19mm in size and one cohort for serrated lesions 10mm or larger.

Conditions

• Colon Cancer
• Colon Polyp
• Colon Adenoma
• Serrated Polyp

Interventions

PROCEDURE

Cold Snare Piecemeal Resection (CSPR)

Qualifying polyps randomized to Cold Snare Piecemeal Resection (CSPR) will be removed using cold snare techniques (no electrocautery, no submucosal injection.)

PROCEDURE

Cold Snare Endoscopic Mucosal Resection (Cold EMR)

Qualifying polyps randomized to Cold Snare Endoscopic Mucosal Resection (Cold EMR) will be removed using cold snare techniques (no electrocautery, with submucosal injection.)

Sponsors & Collaborators

• Rush University Medical Center

  collaborator OTHER

• University of Colorado, Denver

  collaborator OTHER

• John D. Dingell VA Medical Center

  collaborator FED

• White River Junction Veterans Affairs Medical Center

  collaborator FED

• University of Kansas Medical Center

  collaborator OTHER

• Vancouver Coastal Health

  collaborator OTHER_GOV

• Université de Montréal

  collaborator OTHER

• University of Alabama at Birmingham

  collaborator OTHER

• Indiana University

  lead OTHER

Principal Investigators

• John J Guardiola, MD · Indiana University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-09-06

Primary Completion

2027-07-31

Completion

2028-07-31

Countries

• United States

Study Locations