Colon cancer is a malignant neoplasm arising in the colon and is commonly discussed within the broader colorectal cancer spectrum. It develops from cells in the large bowel and represents the largest subgroup of colorectal cancers.
Johnson & Johnson agreed to buy Firefly Bio for $1 billion to advance KRAS-targeted cancer therapies. The company also announced a $1 billion cell therapy manufacturing plant in Pennsylvania as part of a $55 billion US investment plan.
A study finds that FABP2 suppresses colon cancer liver metastasis by increasing ferroptosis sensitivity via β-catenin/GPX4 pathway regulation. Low FABP2 expression correlates with poor survival in advanced colon cancer.
Preclinical studies reveal that fructose promotes metastasis in ovarian cancer by reducing cell adhesion, while brigatinib enhances PARP inhibitor efficacy by blocking an early adaptive resistance mechanism. The findings suggest dietary modifications and repurposing a lung cancer drug could improve outcomes for high-grade serous ovarian cancer patients.
New studies reveal how cancer cells survive chemotherapy: fructose promotes ovarian cancer spread, platinum-treated 'zombie cells' release TGFβ in lung and ovarian cancers, and mitochondrial metabolism drives 5FU resistance in colorectal cancer. The findings point to potential combination therapy targets.
Colorectal Cancer Alliance tackles rising young-onset cases with Never Too Young Taskforce and Project Cure CRC; LEAD FROM BEHIND wins Webby Award. Screening changes make 20M more eligible.
Rural cancer death rates are highest while big-city rates are lowest, a study of 28 million deaths found. However, separate research shows rural lung and colon cancer patients treated locally had similar outcomes to those at urban centers.
A study in stage 3 dMMR colon cancer found that atezolizumab plus chemotherapy after surgery cut recurrence and death risk by 50%. The trial enrolled 712 patients and the regimen is now included in treatment guidelines.
Karmanos and the Detroit Public Library have opened registration for the 2026 Community Conversations on Cancer series. Three sessions will address colon cancer, implicit bias in care, and multiple myeloma.
Wafik S. El-Deiry highlighted p53 research and the August 2025 approval of dordaviprone/modeyso, the first treatment for diffuse gliomas with H3K27M mutations. Separate posts also described glioblastoma precision oncology discussions and a lifetime achievement award in Mumbai.
A novel therapeutic vaccine using structural nanomedicine principles has shown promising results against HPV-driven cancers in preclinical models. The spherical nucleic acid vaccine design significantly slowed tumor growth and extended survival by generating potent T-cell responses. Unlike preventive HPV vaccines, this approach is designed to treat established cancers caused by the virus.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07781774 |
Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach |
NOT_YET_RECRUITING | NA |
| NCT07744139 |
Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis |
NOT_YET_RECRUITING | |
| NCT07736131 |
Learning Curve of SILS in CRC |
COMPLETED | |
| NCT07732686 |
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry |
NOT_YET_RECRUITING | |
| NCT07725692 |
Predictors of Rescue Surgery, Mortality, and Permanent Stoma After Anastomotic Leak Following Colorectal Cancer Resection |
COMPLETED | |
| NCT07720505 |
COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green |
NOT_YET_RECRUITING | |
| NCT07705334 |
A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors |
RECRUITING | PHASE1 |
| NCT07701408 |
ctDNA and TEP Levels in Colon Cancer |
NOT_YET_RECRUITING | NA |
| NCT07697170 |
Frequency of Care for Peripherally Inserted Central Vascular Access In the Prevention of Marsi |
ENROLLING_BY_INVITATION | NA |
| NCT07673393 |
Improving Prognostication in Colon Cancer |
NOT_YET_RECRUITING |
