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Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.

NCT06327399 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 70

Last updated 2024-03-25

No results posted yet for this study

Summary

Dexmedetomidine bolus dose may provide similar or less hemodynamic changes (less bradycardia and less hypertension) than infusion dose during induction of anaesthesia and tracheal intubation.

Conditions

  • Dexmedetomidine
  • Intubation Complication

Interventions

DRUG

Dexmedetomidine infusion

patients will receive Dexmedetomidine infusion dose of 1 mcg/kg over 10 min before induction.

DRUG

Dexmedetomidine bolus

patients will receive Dexmedetomidine bolus dose of 0.3 mcg/kg over 60 seconds.

DRUG

Atropine Sulfate

If heart rate falls below 45 bpm, rescue dose (500 mcg) of atropine will be given.

DRUG

Ephedrine

If mean blood pressure decreases below 50 mmHg, boluses of 10 mg ephedrine will be given

DRUG

Propofol

Propofol 20 mg boluses till loss of contact

Sponsors & Collaborators

  • Kasr El Aini Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-21
Primary Completion
2024-04-30
Completion
2024-05-31

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06327399 on ClinicalTrials.gov