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Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia

NCT02777619 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 64

Last updated 2016-07-28

No results posted yet for this study

Summary

The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).

Conditions

  • Pharmacodynamic Interaction

Interventions

DRUG

0.0ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.0ng/ml

DRUG

0.4ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.4ng/ml

DRUG

0.6ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.6ng/ml

DRUG

0.8ng/ml Dexmedetomidine

Dexmedetomidine target plasma concentration is 0.8ng/ml

DRUG

Propofol

Sponsors & Collaborators

  • Guangzhou General Hospital of Guangzhou Military Command

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-31
Primary Completion
2016-06-30
Completion
2016-07-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02777619 on ClinicalTrials.gov