MedTrace Logo

Cerebral Vascular Effects of Dexmedetomidine Versus Propofol Sedation in Intubated Mechanically Ventilated ICU Patients

NCT03285165 · Status: SUSPENDED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2020-07-14

No results posted yet for this study

Summary

Serial transcranial Doppler (TCD) exams in healthy volunteers and in animal models showed a strong linear relationship between middle cerebral artery (MCA) flow velocity (FV) and dexmedetomidine infusion. The concomitant elevation of pulsatility index (PI) indicates vasoconstriction of the cerebral vasculature as the most profound underlying mechanism.

Conditions

  • Sedation

Interventions

DRUG

0.2-0.7 mcg/kg/h dexmedetomedine infusion.

patients will receive dexmedetomidine 0.2-0.7 mcg/kg/h infusion for 24h.

DRUG

10-70 mcg/kg/h propofol infusion.

Patients will receive 10-70 mcg/kg/h propofol infusion for 24h.

Sponsors & Collaborators

  • Assiut University

    lead OTHER

Principal Investigators

  • Hala S Abdelghaffar, MD · Assisstant professor in anesthesia and intensive care, faculty of medicine, Assiut university, Egypt

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-14
Primary Completion
2021-09-16
Completion
2021-09-16

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03285165 on ClinicalTrials.gov