Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia Consortium

Summary

Biomarkers for Vascular Contributions to Cognitive Impairment and Dementia (MarkVCID) is an NIH-funded consortium dedicated to finding biomarkers involved in age-related thinking and memory problems. Alzheimer's disease and other dementias leave signatures on brain scans or in the blood called biomarkers. The MarkVCID study will measure a panel of candidate biomarkers in 1800 participants and watch them closely to see what they tell us about changes in brain function and risk of memory loss.

Age-related problems in thinking and memory represent some of the greatest risks to public health in the US and globally. Diseases that affect small blood vessels in the brain have been shown to be major contributors to these changes. However, research and patient care can be held back by limited biomarkers that identify who should be treated.

The MarkVCID Consortium includes 17 US medical centers, a Coordinating Center, an External Advisory Committee, and NIH leadership. Data and biospecimens collected as part of this research study will be stored in a research database and biorepositories, so that researchers can use this information to study brain function.

Conditions

• Cognitive Impairment
• Dementia

Interventions

OTHER

No interventions

This is an observational study with no interventions.

Sponsors & Collaborators

• Duke University

  collaborator OTHER

• Johns Hopkins University

  collaborator OTHER

• University of New Mexico

  collaborator OTHER

• University of Southern California

  collaborator OTHER

• University of Kentucky

  collaborator OTHER

• Rush University Medical Center

  collaborator OTHER

• University of Maryland, Baltimore

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• University of California, Los Angeles

  collaborator OTHER

• University of California, Davis

  collaborator OTHER

• University of Texas

  collaborator OTHER

• The University of Texas Health Science Center at San Antonio

  collaborator OTHER

• The University of Texas Health Science Center, Houston

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• University of Mississippi Medical Center

  collaborator OTHER

• Washington University School of Medicine

  collaborator OTHER

• Olive View-UCLA Education & Research Institute

  collaborator OTHER

• Massachusetts General Hospital

  lead OTHER

Principal Investigators

• Steven M. Greenberg, MD, PhD · Massachusetts General Hospital

Eligibility

Min Age

60 Years

Max Age

90 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-09-29

Primary Completion

2027-07-31

Completion

2027-07-31

Countries

• United States

Study Locations