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The Effect of Vasopressor Therapy on Renal Perfusion in Septic Shock

NCT06234592 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2025-04-04

No results posted yet for this study

Summary

Acute kidney injury (AKI) is a common complication of septic shock and together these conditions carry a high mortality risk. In septic patients who develop severe AKI renal cortical perfusion is deficient despite normal macrovascular organ blood flow. This intra-renal perfusion abnormality may be amenable to pharmacological manipulation, which may offer mechanistic insight into the pathophysiology of septic AKI. The aim of the current study is to investigate the effects of vasopressin and angiotensin II on renal microcirculatory perfusion in a cohort of patients with septic shock.

Conditions

Interventions

DRUG

Angiotensin II

Angiotensin II infusion

DRUG

Vasopressin

Vasopressin infusion

DRUG

Norepinephrine

Standard care vasopressor therapy, norepinephrine infusion

Sponsors & Collaborators

  • European Society of Intensive Care Medicine

    collaborator OTHER

  • Royal Centre for Defence Medicine

    collaborator OTHER_GOV

  • King's College Hospital NHS Trust

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-05
Primary Completion
2026-01-31
Completion
2026-07-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06234592 on ClinicalTrials.gov