Acute kidney injury (AKI) is a sudden decrease in kidney function that develops within days and is detected by rising serum creatinine and/or reduced urine output. It is clinically important because it is common in hospitalized and critically ill patients and is associated with major complications.
A multicenter retrospective cohort study of 17 patients with type 2 diabetes and end-stage renal disease found injectable semaglutide was associated with descriptive changes in glycemic control and body weight. No cardiovascular deaths, nonfatal myocardial infarctions, or nonfatal strokes were observed during follow-up.
Crohn’s disease is linked to kidney stones, dehydration and rare serious kidney complications. Monitoring, hydration and attention to medication-related risks can help protect kidney health.
A February 2026 review analyzes strategies for kidney-targeted drug delivery systems, examining renal targeting mechanisms and nanocarrier platforms. The review highlights how functionalized nanoparticles can achieve enhanced renal specificity while addressing remaining translational challenges in the field.
Finerenone met its primary endpoint in reducing albuminuria in type 1 diabetic kidney disease, marking the first successful drug trial in 30 years for this population. Separately, SGLT2 inhibitors showed superior kidney protection compared to GLP-1 medications in type 2 diabetes patients.
New studies show SGLT2 inhibitors and GLP-1 receptor agonists reduce risks of kidney failure, cardiovascular events, and liver complications in patients with type 2 diabetes, with particularly strong benefits in those with cirrhosis.
The U.S. Food and Drug Administration has granted 510(k) clearance for Argos Infinity, Retia Medical's cardiovascular intelligence software platform designed for high-risk surgical and critical care environments across health systems.
Real-world study finds SGLT2 inhibitors reduce chronic kidney disease and acute kidney injury risk more effectively than GLP-1 receptor agonists in patients with type 2 diabetes, with greatest benefits in those without preexisting kidney disease.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07604662 |
Real-Time Acute Kidney Injury Perioperative Prediction Clinical Trial |
NOT_YET_RECRUITING | NA |
| NCT07569588 |
Improving Patient Assessment After Acute Kidney Injury (AKI) |
RECRUITING | |
| NCT07569406 |
Use of Oxiris Filter in Septic Shock Patients Requiring Renal Replacement Therapy: A Retrospective Cohort Study |
COMPLETED | |
| NCT07568275 |
Comparison of Angiotensin II to Standard Dose Vasopressors on Change in Arterial Elastance |
ACTIVE_NOT_RECRUITING | EARLY_PHASE1 |
| NCT07556107 |
The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS) |
NOT_YET_RECRUITING | PHASE4 |
| NCT07550894 |
Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT |
NOT_YET_RECRUITING | PHASE3 |
| NCT07549243 |
Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Acute Kidney Injury in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass |
ENROLLING_BY_INVITATION | NA |
| NCT07546448 |
Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment |
NOT_YET_RECRUITING | |
| NCT07542353 |
Clinical Impact of Different Crystalloid Solution on Early Biomarkers of Kidney Injury After Lumbar Fusion Surgery in Elderly Patients |
COMPLETED | NA |
| NCT07529990 |
Impact of Sodium Profiling During Haemodialysis on Haemodynamic Tolerance and Sonographic Extravascular Lung Water in Shocked Patients With Acute Kidney Injury |
COMPLETED |
