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The Effects of Blood Pressure on Renal Function and Oxygenation in Septic Shock

NCT02453425 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 8

Last updated 2017-04-25

No results posted yet for this study

Summary

The purpose of this study is to evaluate renal effects of 3 different levels of mean arterial pressure in early case of septic shock. In 8 patients diagnosed with early septic shock, we will adjust mean arterial pressure (MAP) to three different levels, using norepinephrine. At each level of MAP, central and renal hemodynamics and oxygenation states will be measured. Analysis will be made to describe the pathophysiology at MAP 75 mmHg, and then to evaluate at which MAP renal function and oxygenation is least affected negatively.

Conditions

Interventions

OTHER

MAP 60 mmHg

Norepinephrine adjusted to reach MAP 60 mmHg

OTHER

MAP 75 mmHg

Norepinephrine adjusted to reach MAP 75 mmHg

OTHER

MAP 90 mmHg

Norepinephrine adjusted to reach MAP 90 mmHg

Sponsors & Collaborators

  • Sahlgrenska University Hospital

    lead OTHER

Principal Investigators

  • Sven-Erik Ricksten, Professor · Sahlgrenska University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-05-31
Primary Completion
2017-03-31
Completion
2017-03-31

Countries

  • Sweden

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02453425 on ClinicalTrials.gov