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Effect of Gastrectomy on Gut Microbiome and Cognitive Function

NCT06186089 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2024-04-11

No results posted yet for this study

Summary

Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years. Studies suggests that gastrointestinal surgery may affect the gut microbiota, and the effect varies between surgical procedures. In this study, the investigators will compare the differences of gut microbiota between total gastrectomy and double-tract reconstruction, to investigate the effect of gastric acid on the gut microbiota colonizing, and the effect of different surgical procedures on the postoperative cognitive function of proximal gastric cancer patients.

Conditions

Interventions

DIETARY_SUPPLEMENT

probiotics

patients undergoing total gastrectomy take probiotics qd for 3 months

Sponsors & Collaborators

  • Jiangjiang Bi

    lead OTHER

Principal Investigators

  • Jiangjiang Bi, MD · Tongji Hospital

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-20
Primary Completion
2025-12-31
Completion
2026-06-30

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06186089 on ClinicalTrials.gov