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Effects of a High-fat Meal on Exercise-mediated Sympatholysis

NCT06186050 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2024-09-19

No results posted yet for this study

Summary

The goal of this trial is to examine the effects of a single high-fat meal with or without the co-ingestion of dietary nitrate on exercise-mediated sympatholysis. The main questions it aims to answer are:

1. What are the mechanisms responsible for reduced exercise-mediated sympatholysis following a high-fat meal
2. Can dietary nitrate prevent the declines in exercise-mediated sympatholysis

Participants will be asked to complete three study visits in a randomized order:

1. Low-fat meal
2. High-fat meal
3. High-fat meal plus dietary nitrate

Exercise-mediated sympatholysis will be measured using Doppler ultrasound via a protocol involving rhythmic handgrip exercise and a lower body negative pressure stimulus. Sympatholysis will be assessed before each meal, and at 1, 2, and 3 hours post-prandial.

Conditions

  • Diet, Healthy

Interventions

DIETARY_SUPPLEMENT

Beetroot drink

Drink containing 10g of beetroot powder in 250 mL cold tap water

DIETARY_SUPPLEMENT

Placebo

Mio flavouring in 250 mL cold tap water. Trace amounts of sugar and sodium were added to match the content in the beetroot supplement

DIETARY_SUPPLEMENT

Control

Low-fat meal with cornflakes, greek yogurt, skim milk, and orange juice

Sponsors & Collaborators

  • University of Guelph

    lead OTHER

Principal Investigators

  • Philip Millar, PhD · University of Guelph

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-01-08
Primary Completion
2024-07-30
Completion
2024-07-30

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06186050 on ClinicalTrials.gov