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The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma

NCT06138340 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 120

Last updated 2025-02-14

No results posted yet for this study

Summary

Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.

Conditions

  • Brain Network Connectivity
  • Postoperative Delirium
  • Dexmedetomidine
  • Propofol

Interventions

DRUG

Dexmedetomidine

Participants will be sedated and maintained by dexmedetomidine during the surgery.

DRUG

Propofol

Participants will be sedated and maintained by propofol during the surgery.

DRUG

Remimazolam Injection

Participants will be sedated and maintained by remimazolam during the surgery.

Sponsors & Collaborators

  • Beijing Tiantan Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-31
Primary Completion
2025-11-30
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06138340 on ClinicalTrials.gov