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Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients

NCT06619912 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 686

Last updated 2025-07-22

No results posted yet for this study

Summary

Delirium is a common consequence of cardiac surgery and associates with poor outcomes. Multiple causes can trigger delirium occurence, and it has been hypothesised that sleep disturbances can be one of them. Dexmedetomidine may be effective in reducing delirium. The aim of this study was to demonstrate preoperative dexmedetomidine nasal spray in cardiac surgery patients can reduce postoperative delirium by improving preoperative sleep.

Conditions

  • Postoperative Delirium
  • Preoperative Sleep Disorder

Interventions

DRUG

Dexmedetomidine nasal spray

Participants will be randomised to receive either dexmedetomidine or saline nasal spray (1.5ug/kg, ideal body weight) at the night before surgery and 30 minutes before induction.

Sponsors & Collaborators

  • Xijing Hospital

    lead OTHER

Principal Investigators

  • Chong Lei, M.D., phd · Xijing Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-03-03
Primary Completion
2026-10-31
Completion
2027-03-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06619912 on ClinicalTrials.gov