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Effect of Dexmedetomidine on Recovery Profiles of Elderly Patients

NCT01851005 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2014-03-19

No results posted yet for this study

Summary

Emergence of elderly patients from anesthesia may face with cognitive dysfunction or agitation such as delirium. There are reports that using dexmedetomidine as a adjuvant for general anesthesia decreased emergence-agitation in children and dexmedetomidine may be used for treating deliriums. Thus, we thought that dexmedetomidine as a adjuvant agent may be a help to smooth emergence from anesthesia in elderly.

The aims of this study were to investigate the recovery characteristics (time to recovery of consciousness (ROC) and recovery, bispectral index (BIS) values at ROC and orientation, and Ricker sedation-agitated scale at the postanesthetic care unit) and safety (vital signs during and after administration of dexmedetomidine) of dexmedetomidine in elderly patients undergoing elective surgery.

Conditions

  • Elderly Patients
  • Anesthesia
  • Emergence From Anesthesia
  • Effects of Dexmedetomidine
  • Recovery From Anesthesia

Interventions

DRUG

Dexmedetomidine

Infusion of dexmedetomidine (0.4 ug/kg/hr)

DRUG

Sevoflurane

Control Vol% to maintain BIS 40\~45

DRUG

Propofol and Remifentanil

Control effect site concentration for maintain BIS 40\~45 and changes of vital signs within 20%.

DRUG

Normal saline

Use as placebo

DRUG

Rocuronium

0.8 mg/kg for induction

Sponsors & Collaborators

  • Chosun University Hospital

    lead OTHER

Principal Investigators

  • Ki Tae Jung, M.D. · Department of Anesthesiology and Pain medicine School of Medicine, Chosun University

Study Design

Allocation
RANDOMIZED
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-05-31
Primary Completion
2014-02-28
Completion
2014-02-28

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01851005 on ClinicalTrials.gov