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Postoperative Dexmedetomidine in Prevention of Postoperative Delirium

NCT06382961 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 287

Last updated 2024-05-24

No results posted yet for this study

Summary

The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are :

1. Does postoperative dexmedetomidine reduce the incidence of delirium after lung surgery?
2. Does postoperative dexmedetomidine introduce other medical problems? Researchers will compare dexmedetomidine and sufentanil to see if dexmedetomidine works to reduce delirium.

Participants will undergo routine postoperative care:

1. Patient-controlled self anesthesia with sufentanil only or combination of sufentanil and dexmedetomidine
2. Postoperative visit twice a day for at least seven days

Conditions

  • Delirium in Old Age
  • Anesthesia; Adverse Effect

Interventions

DRUG

Dexmedetomidine injection

Combining with 3 μg.kg-1 sufentanil, 3 μg.kg-1 dexmedetomidine is injected through intravenous patient controlled anesthesia pump in a 2 ml bolus with 20 minutes lock-out, and a background infusion rate of 2 ml per hour.

DRUG

Sufentanil injection

3 μg.kg-1 sufentanil is injected through intravenous patient controlled anesthesia pump in a 2 ml bolus with 20 minutes lock-out, and a background infusion rate of 2 ml per hour.

Sponsors & Collaborators

  • Shenzhen People's Hospital

    collaborator OTHER

  • Dongyuan People's Hospital

    collaborator UNKNOWN

  • Kunming Children's Hospital

    collaborator OTHER

  • Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.

    lead INDUSTRY

Principal Investigators

  • Rui Zhao · Department of Anesthesiology, Kunming Children's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-11
Primary Completion
2024-03-06
Completion
2024-04-28

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06382961 on ClinicalTrials.gov