MedTrace Logo

Changes in Host Gene Expression to Differentiate Between Systemic Inflammation and Infection After Major Surgery

NCT06116656 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 61

Last updated 2026-04-27

No results posted yet for this study

Summary

Changes in host gene expression may provide additional information to diagnose postoperative infection and improve outcome after surgery. This study aims to validate the early diagnostic performance of specific gene signatures for differentiating infection from non-infected SIRS or uncomplicated postoperative course in blood sampes of adult patients undergoing major noncardiac surgery.

Conditions

Interventions

DIAGNOSTIC_TEST

blood leucocyte transcriptomics

the analysis of the RNA transcripts produced by the genotype at a given time that provides a link between the genome, the proteome, and the cellular phenotype.

Sponsors & Collaborators

  • Amphia Hospital

    collaborator OTHER

  • St. Antonius Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-01
Primary Completion
2025-03-01
Completion
2025-03-01

Countries

  • Netherlands

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06116656 on ClinicalTrials.gov