MedTrace Logo

Post-surgery Systemic Inflammation and Neuro-immune Interactions

NCT03055325 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2024-01-17

No results posted yet for this study

Summary

The aim is to map the inflammatory response after surgery and further investigate the mechanisms by which inflammation is regulated. The inflammatory cascade is pivotal in protecting organisms against invading pathogens and in enabling healing of damaged tissues, yet the cascade itself may be harmful to the organism when excessive (e g septic chock).

The increased immune-reactivity after trauma, such as surgery, is furthermore associated with post-operative declines in memory and learning capacity, a condition likely related to the notion of "sickness behavior". The effects on the brain after surgery and the associated neuro-immune crosstalk will now be investigated with focus on changes in immune reactivity in peripheral blood after surgery.

Conditions

Interventions

OTHER

Observational study of patients undergoing surgery

Cognitive testing, testing of heart rate variability and collection of blood samples

Sponsors & Collaborators

Principal Investigators

  • Lars I Eriksson · Department of Physiology and Pharmacology, Karolinska Institutet

Eligibility

Min Age
45 Years
Max Age
75 Years
Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2022-12-31
Completion
2023-12-31

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03055325 on ClinicalTrials.gov