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Perioperative Inflammatory Response Assessment in High-risk Patients Undergoing Noncardiac Surgery

NCT04753307 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 1400

Last updated 2023-08-14

No results posted yet for this study

Summary

Postoperative cardiovascular complications are common after noncardiac surgery. The association between perioperative inflammation and the occurrence of cardiovascular complications after surgery is still unknown. Therefore, we will evaluate as our primary aim the association between patients with increased postoperative inflammation, assessed with C-reactive protein measurements, and the occurrence of major cardiovascular complications after noncardiac surgery. We will further evaluate the influence of perioperative inflammation on the occurrence of postoperative acute kidney injury. We will also evaluate the association between inflammation and the influence on Days-At-Home within 30 days. Furthermore, we will evaluate the association between increased inflammatory biomarkers and postoperative N-terminal pro brain natriuretic peptide (NT-proBNP) concentration.

Conditions

  • Postoperative Complications
  • Cardiovascular Complication
  • Myocardial Ischemia
  • Inflammation

Interventions

DIAGNOSTIC_TEST

Laboratory measurements

Inflammatory and cardiac biomarkers will be measured before surgery, and on the first, second, third and fifth postoperative day

Sponsors & Collaborators

  • Medical University of Graz

    collaborator OTHER

  • Medical University of Vienna

    lead OTHER

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-19
Primary Completion
2024-01-31
Completion
2025-01-31

Countries

  • Austria

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04753307 on ClinicalTrials.gov