Timing of Endoscopy in Cirrhotic Patients with Acute Variceal Bleeding

Summary

Endoscopy is important for the diagnosis and treatment of acute upper gastrointestinal bleeding (AUGIB), especially acute variceal bleeding (AVB), in patients with liver cirrhosis. However, the optimal timing of endoscopy remains controversial, primarily because the currently available evidence is of poor quality, and the definition of early endoscopy is also very heterogeneous among studies. Herein, a multicenter randomized controlled trial (RCT) is performed to explore the impact of timing of endoscopy on the outcomes of cirrhotic patients with AVB.

Conditions

• Acute Upper Gastrointestinal Bleeding
• Acute Variceal Bleeding

Interventions

PROCEDURE

Endoscopy

Endoscopy

Sponsors & Collaborators

• General Hospital of Shenyang Military Region

  lead OTHER

Principal Investigators

• Xingshun Qi, MD · General Hospital of Shenyang Military Area

• Yiling Li, MD · First Hospital of China Medical University

• Bimin Li, MD · The First Affiliated Hospital of Nanchang University

• Xuefeng Luo, MD · West China Hospital

• Xiaofeng Liu, MD · The 960th Hospital of the Chinese People's Liberation Army

• Chunqing Zhang, MD · Affiliated Provincial Hospital of Shandong First Medical University

• Mingkai Chen, MD · People's Hospital of Wuhan University

• Derun Kong, MD · The First Affiliated Hospital of Anhui Medical University

• Fernando G Romeiro, MD · Botucatu Medical School

• Andrea Mancuso, MD · Azienda di Rilievo Nazionale ad Alta Specializzazione Civico-Di Cristina-Benfratelli

• Nahum Méndez-Sánchez, MD · Medica Sur Clinic and Foundation

• Enqiang Linghu, MD · The First Medical Center of Chinese PLA General Hospital

• Yunhai Wu, MD · The Sixth People's Hospital of Shenyang

• Metin Basaranoglu, MD · Bezmialem Vakif University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-09-04

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• China

Study Locations