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Effect of Portal Vein Thrombosis on the Prognosis of Liver Cirrhosis

NCT02335580 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 475

Last updated 2023-02-24

No results posted yet for this study

Summary

The prevalence of portal vein thrombosis (PVT) in patients with liver cirrhosis is 5-20%. Current evidence regarding the effect of portal vein thrombosis on the prognosis of cirrhotic patients remains under debate. Considering that PVT potentially elevates the portal pressure and thereby increase the risk of variceal bleeding, we focus on the patients with high-risk varices and variceal bleeding as the study population. Thus, the main goals are to analyze the effect of PVT on the incidence of first variceal bleeding in patients without any prior bleeding history but with high-risk varices, the incidence of recurrent variceal bleeding in patients with a history of variceal bleeding, and the treatment failure rate of variceal bleeding in patients with acute variceal bleeding. Certainly, the survival is also observed in all patients.

Conditions

Interventions

DRUG

Somatostatin and its analogs

Somatostatin and/or octreotide will be intravenously infused.

PROCEDURE

Endoscopic sclerotherapy, endoscopic variceal ligation, endoscopic tissue glue injection

Endoscopic sclerotherapy, endoscopic variceal ligation, and/or endoscopic tissue glue injection will be performed based on the endoscopists' choice.

Sponsors & Collaborators

  • General Hospital of Shenyang Military Region

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-12-31
Primary Completion
2022-12-31
Completion
2022-12-31

Countries

  • China

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02335580 on ClinicalTrials.gov