TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Portal Vein Thrombosis

Summary

portal vein thrombosis may be a negative prognostic marker of variceal bleeding in liver cirrhosis. Compared with conventional endoscopic and pharmacological therapy, transjugular intrahepatic portosystemic shunt may further improve the outcomes of portal vein thrombosis in liver cirrhosis with variceal bleeding.

Conditions

• Portal Vein Thrombosis
• Liver Cirrhosis

Interventions

PROCEDURE

Transjugular intrahepatic portosystemic shunt

Transjugular intrahepatic portosystemic shunt refers to an interventional radiological procedure by placing a stent between portal vein and hepatic vein. No specific device was used in the Interventional field.

DRUG

Non-selective beta blockers

Non-selective beta blockers are the drugs for reducing the portal pressure.

PROCEDURE

Endoscopic therapy

Endoscopic therapy includes the endoscopic variceal band ligation

DRUG

Anticoagulation

Anticoagulation therapy includes heparin and warfarin.

Sponsors & Collaborators

• The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

  collaborator OTHER

• Shandong Provincial Hospital

  collaborator OTHER_GOV

• Third Affiliated Hospital, Sun Yat-Sen University

  collaborator OTHER

• Southern Medical University, China

  collaborator OTHER

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• The First Affiliated Hospital of Nanchang University

  collaborator OTHER

• Air Force Military Medical University, China

  lead OTHER

Principal Investigators

• Guohong Han, MD · Xi'an International Medical Center Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-09

Primary Completion

2024-12-31

Completion

2024-12-31

Countries

• China

Study Locations