MedTrace Logo

The Effect of Anthropometrics on Desflurane Rise Time

NCT06026033 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 361

Last updated 2023-12-22

No results posted yet for this study

Summary

Desflurane is increasingly used in general anesthesia. Its pharmacokinetic properties are known and its distribution is easily modeled. Yet these models fail in practice. In order to increase accuracy, any model should include cardiac output, alveolar ventilation and alveolar dead space, all of which are either hard to measure or impractical, at least.

A previous study performed by the same investigator showed that time to target endtidal concentration of sevoflurane is prolonged with increased cardiac output, but only if the patient has increased muscle mass. Although desflurane has lower muscle and fat solubility, our observations suggest a similar prolongation in case of increased muscle mass.

The investigators aim to investigate if patient characteristics such as gender, age, height, weight, body type prolongs time to reach target endtidal desflurane concentration in low flow anesthesia.

Conditions

  • Desflurane
  • Anesthesia, General

Interventions

DRUG

Desflurane induction

Following tracheal intubation, the fresh gas flow will be set to 1 liters/minute, desflurane vaporizer will be set to maximum.

Sponsors & Collaborators

  • Recep Tayyip Erdogan University

    lead OTHER

Principal Investigators

  • Başar Erdivanlı, Assoc. Prof. · Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation

  • Alihan Madran, M.D. · Recep Tayyip Erdogan University Medical Faculty, Department of Anesthesiology and Reanimation

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-02-01
Primary Completion
2023-08-30
Completion
2023-09-01

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06026033 on ClinicalTrials.gov