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Pain Treatment With Combinations of NSAIDs

NCT05994287 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 105

Last updated 2024-01-25

No results posted yet for this study

Summary

The search for new safe and effective methods of pain relief after surgery on large joints is still an urgent problem. The most optimal approach in the treatment of postoperative pain is the use of multimodal analgesia with a different mechanism of action that act on various mechanisms of pain and can include opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, anticonvulsants, NMDA antagonists, alpha-2-agonists, and sodium and calcium channel blocking agents, as well as local anesthetics. NSAIDs are the most popular and safe means for pain relief. Therefore, a lot of efforts are aimed at increasing the effectiveness of NSAIDs use. The aim of this study was to evaluate the effectiveness of simultaneously administering two or three NSAIDs, compared to using only one NSAID, for pain relief after surgery on large joints such as hip or knee arthroplasty.

Conditions

  • Postoperative Pain, Acute

Interventions

DRUG

Aspirin

The patients received aspirin in a dose of 100 mg orally daily.

DRUG

Ketorolac

The patients received ketorolac in a dose of 90 mg mg orally daily.

DRUG

Celecoxib

The patients received celecoxib in a dose of 400 mg orally daily.

Sponsors & Collaborators

  • Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty

    lead OTHER

Principal Investigators

  • Vladimir U. Emelianov, MD PhD · Federal Center for Traumatology, Orthopedics and Arthroplasty, Cheboksary, Russia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-01
Primary Completion
2022-01-01
Completion
2023-01-01

Countries

  • Russia

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05994287 on ClinicalTrials.gov