Multimodal Analgesia in Shoulder Arthroplasty

Summary

Opioid medications are associated with many side effects and the risk of abuse or overdose. Orthopaedic surgeons are currently investigating ways to control pain after surgery while limiting the amount of opioid medications prescribed. One way to reduce the amount of opioid medications prescribed, and potentially avoid opioid-associated adverse events, is to use multiple non-opioid medications and anesthetic drugs before surgery, during surgery, and after surgery. This study aims to evaluate a protocol with non-opioid pain medications to reduce the need for opioid medication after shoulder surgery.

Conditions

• Shoulder Pain
• Opioid Use

Interventions

DRUG

Acetaminophen

Acetaminophen Tablet

DRUG

Celecoxib 200mg

Celecoxib Tablet

DRUG

Celecoxib 400 mg

Celecoxib Tablet

DRUG

Ropivacaine

Ropivicaine nerve block (injection)

DRUG

Ketorolac

ketorolac injection

DRUG

Acetaminophen Injectable Product

Acetaminophen injection

DRUG

Oxycodone

oxycodone tablet

DRUG

Tramadol

Tramadol tablet

DRUG

Morphine Injectable Solution

Morphine Patient Controlled Analgesia

DRUG

hydrocodone bitartrate and acetaminophen

Norco tablet

DRUG

Morphine

morphine injection

DRUG

Oxycodone Hydrochloride

oxycodone hydrochloride tablet

DRUG

Meloxicam

meloxicam tablet

Sponsors & Collaborators

• Rush University Medical Center

  lead OTHER

Principal Investigators

• Gregory P Nicholson, MD · Rush University Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-06-01

Primary Completion

2019-06-01

Completion

2019-06-01

FDA Drug

Yes

Countries

• United States

Study Locations