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Effect of Paracetamol and Ibuprofen Reducing Morphine Requirements After Total Knee Arthroplasty

NCT04414995 · Status: COMPLETED · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2020-12-22

No results posted yet for this study

Summary

Adequate pain management has an important role in supporting early ambulation after the Total Knee Arthroplasty (TKA). Multimodal analgesia is one of the modalities of overcoming postoperative pain. The use of combination Paracetamol and Ibuprofen injection is expected to reduce total morphine consumption after TKA.

Conditions

  • Analgesia

Interventions

DRUG

Paracetamol injection and Ibuprofen injection

Use of combination acetaminophen and ibuprofen to reduce morphine requirement inpatient after Total knee arthroplasty

DRUG

Paracetamol injection and normal saline

Use of paracetamol and normal saline to reduce morphine requirement inpatient after Total knee arthroplasty

DRUG

Ibuprofen Injection and normal saline

Use of ibuprofen and normal saline to reduce morphine requirement inpatient after Total knee arthroplasty

Sponsors & Collaborators

  • Indonesia University

    lead OTHER

Principal Investigators

  • Andri MT Lubis, MD, PhD · Fakultas Kedokteran Universitas Indonesia

  • Aida R Tantri, MD · Fakultas Kedokteran Universitas Indonesia

  • Ludwig AP Pontoh, MD · Fakultas Kedokteran Universitas Indonesia

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
50 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-06-05
Primary Completion
2020-11-30
Completion
2020-12-15

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04414995 on ClinicalTrials.gov