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Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection

NCT03391427 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2023-07-06

No results posted yet for this study

Summary

Lidocaine and ketamine both are being used for perioperative analgesia. Perioperative lidocaine infusion has been shown to reduce postoperative pain and opioid consumption. Perioperative low dose Ketamine has shown improved postoperative pain and reduced opioid usage. We therefore tested the hypothesis that the combination would provide better analgesia in the milieu of intrathecal morphine.

Conditions

  • Hepatectomy

Interventions

DRUG

Lidocaine

This group will receive lidocaine infusion

DRUG

Ketamine

This group will receive Ketamine infusion

DRUG

Lidocaine+ketamine

This group will receive mixture of ketamine and lidocaine infusion

DRUG

Saline

This group will receive saline infusion

Sponsors & Collaborators

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Principal Investigators

  • Achal Dhir · Lawson

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-01
Primary Completion
2015-11-04
Completion
2017-12-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03391427 on ClinicalTrials.gov