Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Summary

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

Conditions

• Nicotine Use Disorder

Interventions

OTHER

E-liquid coolant (No WS-3) for non-menthol (1)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.

OTHER

E-liquid coolant (No WS-3) for low (0.1%) menthol (1)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.

OTHER

E-liquid coolant (No WS-3) for high (2.0%) menthol (1)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants without WS-3.

OTHER

E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.

OTHER

E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.

OTHER

E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-3 concentration.

OTHER

E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.

OTHER

E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.

OTHER

E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-3 concentration.

OTHER

E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.

OTHER

E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.

OTHER

E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with low WS-23 concentration.

OTHER

E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.

OTHER

E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.

OTHER

E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with high WS-23 concentration.

OTHER

E-liquid coolant (4% WS-23) for non-menthol (6)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

OTHER

E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

OTHER

E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)

Adult users of e-cigarette will be exposed to distinct e-liquid coolants with 4% WS-23 concentration.

Sponsors & Collaborators

• National Institute on Drug Abuse (NIDA)

  collaborator NIH

• Yale University

  lead OTHER

Principal Investigators

• Suchitra Krishnan-Sarin, PhD · Yale University

Study Design

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-06-20

Primary Completion

2026-05-31

Completion

2026-05-31

Countries

• United States

Study Locations