C-Protein in Fatigue and Aging

Summary

This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.

Conditions

• Aging
• Muscle Atrophy or Weakness
• Sarcopenia in Elderly
• Sarcopenia

Interventions

BEHAVIORAL

Fatiguing Exercise

Volunteers will perform knee extension exercise of the dominant limb while seated in a chair designed for exercise of the knee extensor muscle group. The chair will be equipped with a lever arm, aligned with the axis of rotation of the knee and fixed to the distal shank, 2 centimeters proximal to the ankle joint. The lever arm will be instrumented to provide resistance and measure velocity. The volunteers will perform 3-5 maximum voluntary contractions (MVC) to determine peak torque. Once established, volunteers will rest for 5 minutes before initiating the fatigue protocol, whereby they will perform repeated MVC of the dominant limb against resistance equal to or less than 50% of MVC until range of motion cannot be maintained. Because the goal of this exercise is to uniformly fatigue the quadriceps muscle group, this exercise will be performed continuously. It is expected to take between 1 and 3 minutes to achieve the desired level of fatigue.

Sponsors & Collaborators

• Wu Tsai Human Performance Alliance

  collaborator UNKNOWN

• National Institutes of Health (NIH)

  collaborator NIH

• Oregon Health and Science University

  collaborator OTHER

• Washington State University

  collaborator OTHER

• National Institute on Aging (NIA)

  collaborator NIH

• University of Oregon

  lead OTHER

Principal Investigators

• Damien M Callahan, Ph.D. · University of Oregon

Study Design

Allocation

NA

Purpose

BASIC_SCIENCE

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-11-06

Primary Completion

2027-01-31

Completion

2027-01-31

Countries

• United States

Study Locations