The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

Summary

This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are:

1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women?
2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women?
3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?

Conditions

• Insulin Resistance
• Impaired Glucose Tolerance
• Obesity
• Metabolic Disturbance

Interventions

BEHAVIORAL

Low Physical Activity and Added Carbohydrate Group

Young men and women will transition into a low physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group. One of the control groups will undergo a low physical activity intervention.

BEHAVIORAL

Low physical Activity Control

Young men and women will transition into a low physically active lifestyle for 10 days.

BEHAVIORAL

High Physical Activity and Added Carbohydrate Group

Young men and women will transition into a high physically active lifestyle for 10 days and consume added sugar-sweetened beverages. The intervention group will be compared to two control groups and one experimental group.

Sponsors & Collaborators

• University of New Hampshire

  lead OTHER

Principal Investigators

• Michael S Brian, PhD · University of New Hampshire

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-02-08

Primary Completion

2026-09-30

Completion

2026-09-30

Countries

• United States

Study Locations