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European Study of Prodromal iNPH

NCT05910944 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2026-04-30

No results posted yet for this study

Summary

To investigate if progression from prodromal into symptomatic NPH can be predicted from advanced neuroimaging, biomarkers in cerebrospinal fluid (CSF) and plasma and investigate the unknown mechanisms causing deterioration by investigating longitudinal changes in the above-mentioned variables. Three different cohorts with both asymptomatic and symptomatic patients as well as healthy controls will be investigated over time, both without intervention and before and after shunt surgery.

Conditions

  • Normal Pressure Hydrocephalus
  • Hydrocephalus

Interventions

PROCEDURE

Shunt surgery

Shunt surgery according to each local centers routine

Sponsors & Collaborators

  • Swedish Society for Medical Research

    collaborator OTHER

  • Johan Virhammar

    lead OTHER

Principal Investigators

  • Johan Virhammar, MD, PhD · Uppsala University Hospital

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-01
Primary Completion
2035-12-31
Completion
2035-12-31

Countries

  • Finland
  • Italy
  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05910944 on ClinicalTrials.gov