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Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus

NCT00004363 · Status: COMPLETED · Type: OBSERVATIONAL

Last updated 2005-06-24

No results posted yet for this study

Summary

OBJECTIVES: I. Determine whether diverse mutations of the vasopressin-neurophysin II (AVP-NPII) gene cause autosomal dominant familial neurohypophyseal diabetes insipidus by directing the production of an abnormal preprohormone.

II. Determine whether the AVP-NPII gene-directed preprohormone accumulates and destroys magnocellular neurons because it cannot be folded and processed efficiently.

Conditions

  • Diabetes Insipidus
  • Diabetes Insipidus, Neurohypophyseal

Interventions

DRUG

chlorpropamide

DRUG

desmopressin

Sponsors & Collaborators

Principal Investigators

  • Gary L. Robertson · Northwestern University

Eligibility

Min Age
6 Months
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1995-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00004363 on ClinicalTrials.gov