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The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH

NCT06857136 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 29

Last updated 2026-02-11

No results posted yet for this study

Summary

The goal of this observational study is to evaluate the role of DTI-ALPS in the diagnostic and therapeutic management of NPH

The main questions it aims to answer are:

* Whether the glymphatic system (GS) is actually impaired in NPH
* Whether DTI-ALPS index can predict the positive response to tap test (TT) and to ventriculo-peritoneal shunt (VPS) surgery.

A healthy control group of patients (HC group) matched for age with the study group, will undergo MR with DTI-ALPS study

Conditions

  • Hydrocephalus
  • Normal Pressure Hydrocephalus

Sponsors & Collaborators

  • Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

    lead OTHER

Principal Investigators

  • Morgan A Broggi, MD · Fondazione IRCCS Istituto Neurologico Carlo Besta

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-15
Primary Completion
2024-08-31
Completion
2024-12-31

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06857136 on ClinicalTrials.gov