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Normal Pressure Hydrocephalus Biomarkers Investigation

NCT05562596 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2022-10-03

No results posted yet for this study

Summary

Normal Pressure Hydrocephalus (NPH) is a clinical condition that induces cognitive deterioration that can be reverted, at least in part, by introducing ventricular-peritoneal diversion controlled by a miniaturized valve system.

Mechanisms involved in such an improvement of cognitive function after liquor diversion are unknown.

Oxysterols are a family of cholesterol-related compounds having diverse biological functions. Among others, they are involved in cholesterol homeostasis in the brain and are detectable in liquor, potentially impacting neurodegeneration.

NPH is an ideal clinical model to study oxysterol distribution in liquor before and after ventricular-peritoneal diversion.

Conditions

Interventions

DIAGNOSTIC_TEST

Measurement of oxysterol profile, including 20 molecules, in liquor before and after surgery

Samples are quantitated by deuterium-labeled mass-spectrometry amalysis.

Sponsors & Collaborators

  • AUSL Latina

    collaborator UNKNOWN

  • University of Roma La Sapienza

    lead OTHER

Principal Investigators

  • Luigi Iuliano, M.D. · University of Roma La Sapienza

  • Gianpaolo Petrella, M.D. · AUSL Latina

Eligibility

Min Age
60 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-10-30
Primary Completion
2024-04-01
Completion
2024-07-01

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05562596 on ClinicalTrials.gov