European Study on Prediction of Outcome in Patients With Idiopathic Normal Pressure Hydrocephalus

Summary

The purpose of the study is to determine the predictive values and prognostic accuracies of CSF dynamic measures, the TAP -TEST (high-volume cerebrospinal fluid withdrawal), resistance to CSF outflow and compliance in the prediction of shunt-treatment outcome in patients with idiopathic normal pressure hydrocephalus.

Conditions

• Normal Pressure Hydrocephalus

Interventions

PROCEDURE

Ventriculo-peritoneal Shunt

Surgical implantation of a ventriculo-peritoneal cerebrospinal fluid shunt with an adjustable valve system using the Codman-Hakim programmable valve system \[pressure settings: 30 - 200 mmH20\]

Sponsors & Collaborators

• Sahlgrenska University Hospital

  collaborator OTHER

• Department of Neurology and Neurosurgery,Westeinde Hospital, Den Haag

  collaborator UNKNOWN

• Uppsala University Hospital

  collaborator OTHER

• University of Copenhagen

  collaborator OTHER

• Unfallkrankenhaus Berlin

  collaborator OTHER

• Universität des Saarlandes

  collaborator OTHER

• University of Padova

  collaborator OTHER

• Masaryk University

  collaborator OTHER

• University of Budapest

  collaborator OTHER

• Hospital Universitari de Bellvitge

  collaborator OTHER

• Hospital General Universitario Gregorio Marañon

  collaborator OTHER

• Neurosurgical Department, Clinique St. Jaen, Brussels, Belgium

  collaborator UNKNOWN

• International Neuroscience Institute Hannover

  lead OTHER

Principal Investigators

• Petra M Klinge, MD · International Neuroscience Institute Hannover

• Carsten I Wikkelsoe, MD · Sahlgrenska University, Gothenburg, Sweden

• Jos TH Tans, MD · Westeinde Hospital, Den Haag, Netherlands

Study Design

Allocation

NA

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2004-10-31

Primary Completion

2008-03-31

Completion

2009-06-30

Countries

• Germany

Study Locations